About us
Unlocking the power of precision drug delivery
Defence Therapeutics is a publicly traded precision intracellular drug-delivery company unlocking the full potential of cancer biologics.
Our Vision
We envision a future where every cancer therapy reaches its full potential. By solving drug delivery at the cellular level, Defence Therapeutics aims to transform existing and next-generation biologics into safe, powerful, first-line, life-changing treatments for patients worldwide.
Our Mission
Our mission is to unlock the full power of complex biologics by increasing their precision delivery using our proprietary drug delivery platform- Accum®. Through our internal & and partnered programs, we are working to increase potency, reduce toxicity, and accelerate the development of cancer therapies that truly improve patient outcomes.
Who We Are
Defence Therapeutics is a publicly traded Canadian biotechnology company committed to making cancer treatment more effective and safer. Using its Accum® precision drug delivery platform, Defence is working to enhance the potency of ADCs and other complex biologics at lower doses, with the goal of reducing side effects and improving access to advanced therapies. By pursing cutting edge science, and collaborating with pharma and biotech partners, Defence strives to bring transformative therapies to patients who need them most.
Behind Defence is a team that combines capital market expertise, scientific innovation, and global pharma experience:
Our Team
Dr. Amie Phinney
President and Chief Executive Officer
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Dr. Phinney is a recognized leader in life sciences commercialization with more than 20 years of experience spanning pharmaceutical R&D, biotech innovation, and strategic ecosystem development. She has held various roles at Abbott and AbbVie, pharmaceutical companies in the United States, directing alliances and leading strategic planning and business operations across global R&D.
More recently, she was senior director of partnerships and business development at adMare BioInnovations, where she supported the creation of multiple biotech ventures emerging from Canadian academia. She brings entrepreneurial experience as a co-founder of Block Biosciences Inc. and Discovery-2-Innovation Life Sciences Consulting, through which she has guided numerous biotech start-ups and academic groups in both the United States and Canada.
Dr. Ryan Simms
Chief Operating Officer and Head of Radiopharmaceuticals
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Ryan Simms, PhD is a biopharmaceutical executive and radiopharmaceutical development leader with 20 years of experience advancing targeted radiopharmaceuticals from discovery through first-in-human clinical studies. He has led multidisciplinary teams across chemistry, radiochemistry, CMC, manufacturing, and technical operations, with extensive experience translating innovative science into clinically and commercially executable development programs.
Prior to joining the company, Ryan served as Vice President of Radio CMC
Development at Abdera Therapeutics, where he led CMC strategy, established clinical, manufacturing and isotope supply chains, and advanced targeted radioligand therapy programs into the clinic. Previously, he held leadership roles at Fusion Pharmaceuticals, directing chemistry, radiochemistry, clinical manufacturing, and external partnerships
supporting multiple clinical-stage programs. Earlier in his career at the Centre for Probe Development and Commercialization (CPDC), he helped establish foundational expertise in actinium-225 radiochemistry and contributed to the development of platform technologies that supported the formation of Fusion Pharmaceuticals.
As an independent consultant, Ryan has advised biotechnology companies on preclinical development, IND/CTA-enabling studies, CMC strategy, manufacturing, and regulatory planning for Phase 0 and Phase I radiopharmaceutical programs. He is recognized for combining deep technical expertise with practical operational leadership to efficiently advance complex development programs to the clinic.
Ryan holds a PhD in Engineering from Queen’s University and completed postdoctoral research in Chemistry at the University of Toronto.
Arnab De
CFO, Corporate Secretary
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Dr. Maxime Parisotto
CSO
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Dr. Maxime Parisotto is a seasoned biochemist with over 20 years of experience spanning academic research, drug development, and innovation. He holds a PhD in biochemistry focused on breast cancer and metabolism and has held postdoctoral fellowships at prestigious institutions, including the IGBMC in Strasbourg, France, and the Université de Montréal. As Senior Analyst, he contributed to significant investment decisions at adMare Bioinnovations. He also holds a graduate certificate in life science entrepreneurship development from Concordia university and graduated with an MBA from Sherbrooke University in April 2025.
Dr. Parisotto has a robust track record of leadership, including managing multidisciplinary teams, contributing to high-impact scientific publications. Before joining adMare, he led research initiatives in cancer biology and stem cells at institutions such as the IRCM and Université de Montréal. He is an active member of the Canadian biotech ecosystem, with an extensive professional network contacts and regular participation in national and international conferences. His research and business interests focus on advancing drug development from discovery to clinical stages and fostering collaborations between academia, industry, and investors to drive innovation in biopharmaceuticals. His scientific expertises are mainly in oncology, protein biochemistry, cell metabolism and stem cells biology.
Board of Directors
Sébastien Plouffe
Executive Chairman and Founder
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Experienced finance professional and entrepreneur with over 25 years of experience in both capital markets and project development. Worked for more than 10 years as a successful VP Senior Investment Advisor with Canadian brokerages firms BMO Nesbitt Burns and Canaccord Genuity Wealth Management, from which he has accumulated considerable expertise in most aspects of raising and managing capital. Over the last 15 years, Mr. Plouffe was instrumental in the success of various Canadian and International private and public companies in sectors such as biotech, mining and technology.
Dr. Amie Phinney
President and Chief Executive Officer
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Dr. Phinney is a recognized leader in life sciences commercialization with more than 20 years of experience spanning pharmaceutical R&D, biotech innovation, and strategic ecosystem development. She has held various roles at Abbott and AbbVie, pharmaceutical companies in the United States, directing alliances and leading strategic planning and business operations across global R&D.
More recently, she was senior director of partnerships and business development at adMare BioInnovations, where she supported the creation of multiple biotech ventures emerging from Canadian academia. She brings entrepreneurial experience as a co-founder of Block Biosciences Inc. and Discovery-2-Innovation Life Sciences Consulting, through which she has guided numerous biotech start-ups and academic groups in both the United States and Canada.
Dr. John Lambert
Director
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Dr. Lambert graduated from Christ’s College, University of Cambridge (England, UK), with a degree in Natural Sciences in 1972. He then earned a Ph.D. in Biochemistry from the University of Cambridge in 1976, working on the structure of glycolytic enzymes under the supervision of Professor Richard N. Perham.
Dr Lambert’s postdoctoral training was at the University of California, Davis (1976 – 1980), working on ribosome structure in the laboratory of Dr Robert R. Traut, and at the University of Glasgow, Scotland, UK (1980 – 1982), working on the arom multienzyme complex in the laboratory of Dr John R. Coggins.
In 1982, Dr. Lambert joined the Dana-Farber Cancer Institute, Harvard Medical School, Boston, as the second scientist recruited to work on the ImmunoGen-funded programs to develop antibody-drug conjugates (ADCs) and immunotoxins as anti-cancer therapeutics.
Dr. Lambert joined ImmunoGen in 1987 when the Company established independent research laboratories in Cambridge, Massachusetts. After working in a variety of roles at the Company, Dr. Lambert served as Chief Scientific Officer from 2008 until 2015. In 2016, he became a Distinguished Research Fellow at the Company until his retirement at the end of 2017. He served on the Executive Committee of the company as Executive Vice President, Research, from 2008 until 2016.
During Dr Lambert’s tenure in leadership roles at ImmunoGen, scientists at the Company invented the ADC technology that ultimately resulted in the Genentech/Roche drug, KADCYLA® (approved in 2013 for treating HER2+ breast cancer), discovered the anti-CD38 antibody that became the Sanofi drug SARCLISA®, and created several other ADC molecules that were taken into clinical development. One of these ADCs is ImmunoGen’s drug ELAHERE® that received accelerated approval from FDA in November 14, 2022, for the treatment of folate receptor alpha-positive, platinum-resistant ovarian cancer, and which was converted to full approval on March 22, 2024 (ImmunoGen was acquired by AbbVie in February 2024).
Since January, 2018, Dr Lambert consults with and/or advises a number of start-up and early-stage Biopharma companies and VC firms on ADC research, ADC technologies, ADC programs and ADC development.
Dr Lambert is the author/co-author of over 125 peer-reviewed scientific publications. In 2016, Dr Lambert was elected as a Fellow of the American Institute for Medical and Biological Engineering (AIMBE). In 2018, he was appointed to an Honorary Professorship at The Queen’s University Belfast, Northern Ireland, UK.
Dr. Philippe Lefrançois
Director
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Dr. Philippe Lefrançois is the Director of Research in the Division of Dermatology at McGill University. He is an Assistant Professor of Medicine, of Pharmacology & Therapeutics, and of Surgery. He is a full-time staff dermatologist at the Jewish General Hospital where he is actively involved in multidisciplinary skin cancer clinics and tumor boards. He is an investigator at the Lady Davis Institute where he established a broad skin cancer biobank and a skin cancer translational genomics laboratory. He leads the Terry Fox Research Institute – Marathon of Hope Cancer Centre Network initiatives on BCC and SCC. He is a member of the Réseau Recherche Cancer – Québec, and Québec Cancer Consortium. His translational activities include collaborations with biotechs to bring novel cancer therapeutics and diagnostics to pre-clinical and phase I studies. Dr. Lefrançois holds a Ph.D. from Yale University, and a M.D. from Université de Montréal. He completed his dermatology residency at McGill. His work on skin cancers has been recognized by the CDA and the AAD.
Dr. John Beaver
Director
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John Beaver is a seasoned biopharmaceutical executive with more than 20 years of leadership experience spanning drug development, translational medicine, biomarker strategy, and neuroimaging across global pharmaceutical and biotechnology organizations.
He most recently served as Vice President and Head of Global Biomarker Discovery & Development at Biogen, where he led a multidisciplinary organization of more than 100 scientists across biomarkers, imaging, bioanalytics, pathology, electrophysiology, clinical pharmacology, and pharmacometrics. In this role, he supported approximately 48 pipeline programs across therapeutic areas and contributed to industry-first FDA accelerated approvals in Alzheimer’s disease and ALS enabled by biomarker-driven strategies. He also served on multiple R&D leadership teams, governance bodies, and partnership steering committees, while overseeing annual operating budgets of $50–85 million.
Prior to Biogen, John held senior leadership roles at AbbVie, where he served as Head of Translational Imaging and was named a Volwiler Research Fellow, as well as at GlaxoSmithKline, where he was a Senior Imaging Scientist at the Clinical Imaging Centre embedded within Imperial College London’s Hammersmith Hospital campus. Earlier in his career, he served as Director of Imaging at Maccine in Singapore and conducted human brain imaging research as a postdoctoral fellow with the UK Medical Research Council at the University of Cambridge.
John is currently Co-Founder and CEO of a stealth-mode biotechnology company in the Greater Boston area, where he is applying his extensive experience in translational science, biomarker innovation, and strategic drug development to advance the next generation of therapeutics.
Sherry Aulin
Director
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Sherry Aulin is a finance executive with more than 20 years of experience working with public companies and in the capital markets. She was most recently Chief Financial Officer of Xenon Pharmaceuticals (NASDAQ: XENE), a neuroscience-focused biopharmaceutical company, where she served for over a decade. During her tenure, she played a key role in the company’s Nasdaq IPO, was instrumental in shaping corporate strategy, and led the company’s financing activities, raising more than US$1 billion in equity capital.
Earlier in her career, Ms. Aulin held senior roles at KPMG LLP, where she provided professional services to publicly traded companies across a range of industries, including life sciences. She brings extensive experience in corporate finance, capital markets, strategic planning, investor relations and public-company operations. Ms. Aulin holds a Bachelor of Commerce from the University of British Columbia and is a Chartered Professional Accountant, Chartered Accountant. She currently serves on the Board of Directors of Life Sciences British Columbia and is a past recipient of Business in Vancouver’s Forty Under 40 award.
Scientific Advisory Board
Rob Leanna
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Rob Leanna, is a seasoned pharmaceutical industry veteran with extensive experience in antibody–drug conjugates (ADC) and drug-linker chemistry. Over his decades-long career with AbbVie Inc. he has led development, scale-up, and regulatory strategy for complex biologics and conjugated therapeutics. Now an independent consultant, he advises biotech companies on ADC CMC and development strategy.
Dr. Sarkis Meterissian
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Dr. Meterissian is a Professor of Surgery and Oncology (tenured), Director of the Breast Center of the MUHC and Head of the MUHC Breast Tumor Site Group. From 2007-2009 he was President of the Canadian Society of Surgical Oncology and from 2013 to 2015 he was President of Breast Surgery International. He has also served as the Medical Advisory Board co-Chair of the Quebec Breast Cancer Foundation since 2012.
Dr. Meterissian is involved in a number of clinical and basic science research projects related to breast cancer. In 1999, along with Dr. Morag Park (the Director of the Goodman Cancer Center), he set-up the McGill Functional Genomics Group which includes an extensive solid and liquid tissue bank for breast cancer. This Tumor Bank has led to a number of landmarks papers including the discovery of the Stromal-derived Protein Predictor (SDPP) published in Nature Medicine in 2008. He presently is involved in clinical research collaborations with the U de M Polytechnique Institute funded by NSERC and translational research projects with Dr. Luke McCaffrey of the Goodman. He is also on the Scientific Committee of the McPeak-Sirois group representing the MUHC. This is a Clinical Trials Research Group bringing together the large cancer centers in the province. As part of this group he has recently set-up a Breast Cancer Metastases Registry supported by major pharma. This registry will include, in a prospective fashion, clinical data on metastatic breast cancers from across the province and their management.
Danny Chui
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Danny Chui, PhD, is an accomplished R&D scientific leader with over 20 years of experience spanning therapeutic antibody discovery, ADC development, and next-generation biologics. His career includes senior scientific roles at Zymeworks, Kairos Therapeutics, Abgenix, Amgen, and adMare BioInnovations.
Dr. Svetlana Selivanova
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Dr. Svetlana Selivanova is a radiochemist with more than 20 years of experience in the development of radiopharmaceuticals from early R&D to first-in-human clinical trials. She holds MSc in chemistry and PhD in radiopharmaceutical chemistry and radiobiology. Currently, she is Section Head for Radiochemistry and Medical Applications at Canadian Nuclear Laboratories (CNL) and adjunct professor at the Faculty of Pharmacy, Université Laval. Before joining CNL, she held senior positions, both in research and management, at CHU de Quebec-Université Laval, Sherbrooke University Hospital, and at the Center for Radiopharmaceutical Sciences of ETH Zurich (Switzerland).
Dr. Selivanova is an active member of several professional societies, currently serving as Executive Member of the Canadian Association of Radiopharmaceutical Scientists, President of the SNMMI Radiopharmaceutical Sciences Council, and member of the SNMMI Committee on Radiopharmaceuticals. Internationally, she serves as expert-consultant for the International Atomic Energy Agency and the European Research Council. Dr. Selivanova research interests are in the development and translation of novel radiopharmaceuticals from bench to clinics and in nuclear imaging as a tool for studying biochemical pathways in vivo. Among major accomplishments are her contribution to R&D and translation effort for the production of technetium-99m with cyclotron, and implementation of investigational prostate cancer radiopharmaceutical targeting prostate-specific membrane antigen.
Our Commitment
Through innovation, partnerships, and a platform-first approach, Defence Therapeutics is committed to delivering smarter, safer, and stronger cancer therapies: shaping the future of precision oncology.


